Volume 10, Issue 11

New and Emerging Options for the Treatment of HIV: Reducing Treatment Burden, Increasing Adherence, and Improving Patient Outcomes

In this issue:

In this issue of eHIV Review, Rohit Rao, MD, PGY2 Internal Medicine Resident and Ethel D. Weld, MD, PhD, Associate Professor of Medicine, Physiology, Pharmacology & Therapeutics at Johns Hopkins University School of Medicine, discuss the evidence for new and emerging treatment regimens for HIV. These regimens include once-daily oral bictegravir plus lenacapavir, four-monthly injectable N6LS plus monthly intramuscular lenacapavir, once-weekly oral islatravir plus lenacapavir, and bimonthly injectable cabotegravir plus rilpivirine. Together, these new and emerging regimens have the potential to reduce treatment barriers, increase treatment adherence, and expand treatment access to improve patient outcomes around the world. Clinicians need greater awareness of the expanding toolkit for HIV treatment regimens to select the most appropriate option for each patient and optimize treatment outcomes.  

Learning objective:

Describe the safety and efficacy of newer and investigational treatments for HIV.

Authors:

Ethel D. Weld, MD, PhD
Ethel D. Weld, MD, PhD

Assistant Professor of Medicine and Pharmacology and Molecular Sciences
Division of Infectious Diseases
Division of Clinical Pharmacology
Johns Hopkins School of Medicine
Baltimore, MD
(she/her/hers)

Rohit Rao, MD
Rohit Rao, MD

Osler Internal Medicine Residency Program
PGY2, Internal Medicine Resident The Johns Hopkins School of Medicine Baltimore, MD

Program Directors:

Justin Alves, RN, FNP-BC, ACRN, CARN, CNE

Nurse Educator
Boston Medical Center
Boston, MA
(he/him/his)

Matthew Spinelli, MD, MAS

Associate Professor
HIV, ID, and Global Medicine
Zuckerberg San Francisco General Hospital
San Francisco, CA
(he/him/his)

Ethel D. Weld, MD, PhD

Assistant Professor of Medicine and Pharmacology and Molecular Sciences
Division of Infectious Diseases
Division of Clinical Pharmacology
Johns Hopkins School of Medicine
Baltimore, MD
(she/her/hers)

Length of activity:

1.0 hour Physicians
1.0 contact hour Nurses

Launch date: May 27, 2026
Expiration date: May 26, 2028