Volume 8, Issue 10

Alternative Inhaled Antibiotic Regimens

In this issue:

For virtually all patients with CF, treatment of chronic respiratory tract Pseudomonas aeruginosa with antibiotics delivered directly to the airway is a fundamental part of their regimen. But is a single inhaled antibiotic enough, or can Pseudomonas be better managed and patient outcomes improved by using multiple inhaled agents? And if so, what’s the best schedule for delivery? What does the evidence say?

In this Issue, Dr. Elliott Dasenbrook from the Cleveland Clinic analyzes what’s known about the use of multiple inhaled agents to treat chronic respiratory Pseudomonas aeruginosa in patients with CF.

Learning objectives:

  • Describe the increased prevalence of cycling multiple inhaled antibiotics for individuals chronically infected with respiratory Pseudomonas aeruginosa. 
  • Summarize the results of current studies investigating various regimens of inhaled antibiotics to treat chronic respiratory Pseudomonas aeruginosa.
  • Explain the challenges in conducting randomized controlled trials of cycling multiple inhaled antibiotics in the current CF treatment era.

Author:

Elliott Dasenbrook, MD, MHS
Elliott Dasenbrook, MD, MHS

Director, Cleveland Clinic
Adult Cystic Fibrosis Program
Cleveland, OH

Program Directors:

Peter J. Mogayzel, Jr., MD, PhD

Professor of Pediatrics
Director, Cystic Fibrosis Center
Johns Hopkins University School of Medicine
Baltimore, MD

Noah Lechtzin, MD, MHA

Director, Adult Cystic Fibrosis Program
Associate Professor of Medicine
Johns Hopkins University School of Medicine
Baltimore, MD

Suzanne Sullivan, RN, BSN

Senior Clinical Nurse
The Johns Hopkins University
Baltimore, MD

Length of activity:

1.0 hour Physicians
1.0 contact hour Nurses

Launch date: July 20, 2019
Expiration date: July 19, 2021