Volume 9, Issue 8

CFTR Modulation and Antibiotic Resistance

In this issue:

Pulmonary infections and exacerbations are all too common among people with cystic fibrosis (CF), and the use of antibiotics (ABX) is universal. Most CF clinicians are aware that improper ABX exposure can lead to resistance, but what do they know about the current associations between pharmacodynamic targets and clinical outcomes? People with CF may have ABX clearance and volume of distribution that are different from those without the disease — but how does that translate into altered dosing regimens? What changes does treatment with highly effective CFTR modulators make in the safety and efficacy of commonly prescribed ABX? 

These are some of the questions Dr. Andrea Hahn, assistant professor of pediatrics and infectious disease specialist at Children’s National Hospital and George Washington University School of Medicine and Health Sciences, discusses in her analysis of the key literature in this issue of eCysticFibrosis Review. 

Learning objectives:

  • Explain the rationale behind the increased dosing regimens and infusion times of ceftaroline and meropenem during the treatment of pulmonary exacerbations in people with cystic fibrosis. 
  • Describe the impact of CFTR-modulating treatment on infection with Pseudomonas aeruginosa in people with cystic fibrosis. 

Author:

Andrea Hahn, MD, MS
Andrea Hahn, MD, MS

Assistant Professor of Pediatrics 
Infectious Disease Specialist 
Children’s National Hospital 
George Washington University School of Medicine and Health Sciences

Program Directors:

Noah Lechtzin, MD, MHA

Director, Adult Cystic Fibrosis Program
Associate Professor of Medicine
Johns Hopkins University School of Medicine
Baltimore, MD

Peter J. Mogayzel, Jr., MD, PhD

Professor of Pediatrics
Director, Cystic Fibrosis Center
Johns Hopkins University School of Medicine
Baltimore, MD

Donna Peeler, RN

Clinical Nurse 
Pediatric Clinic Coordinator 
Johns Hopkins Cystic Fibrosis Center 
Baltimore, MD

Length of activity:

1.0 hour Physicians
1.0 contact hour Nurses

Launch date: September 16, 2020
Expiration date: September 15, 2022